Click here for the Pharmacology Home Page Click here for the UC Irvine Home Page Click here for the School of Medicine Home Page
 
 
 
 

Nayna Sanathara

Nayna Sanathara Entered program summer, 2010
Advisor: Oliver Civelli, Ph.D.
Nayna is a graduate student researcher and can be reached at sanathan@uci.edu.

Nayna is a Sally Casanova Predoctoral Scholar.

Teaching Experience

 

University of California, Irvine (Teaching Assistant, Science Communications for Graduate Student with Loh Down on Science host Sandra Tsing Loh)

Winter 2016

University of California, Irvine (Summer Research Program for Undergraduate Students)

Summer 2015

University of California, Irvine (Mentoring Excellence Certificate)

Spring 2015

University of California, Irvine (Teaching Assistant, Biopharmaceutics and Nanomedicine Lab)

September 2013, 2014, 2015

California State University, Long Beach (Graduate Assistant, Microbiology Lab)

Fall 2007 – Spring 2008

 

 

Professional Experience

 

Graduate Professional Success in the Biomedical Sciences Trainee Council (Student Council Member)

September 2015 - present

  • Assist in organizing and providing feedback to GPS-Biomed program administrators about graduate professional development and career opportunities.

Brews and Brains Meetup, Settebello Pizzeria Napoletana, Newport Coast (Co-founder)

  • Organize a friendly forum in which UCI researchers can practice engaging a general audience in their work by providing a short TED-style talk about their research to the local science-loving public.

March 2015 - present

 

School of Medicine Graduate Student Advisory Council, University of California, Irvine (Student Council Member)

  • Assist the SOM Associate Dean and staff in organizing events aimed to improve graduate student life ranging from social events to professional development seminars.

 

2014 - present

Diverse Educational Community and Doctoral Experience (DECADE), University of California, Irvine (Education Chair)

 

2014 - present

  • Organize workshops, seminars, and journal clubs aimed to inform and increase the number of women and underrepresented minorities receiving doctoral degrees from UCI
  • Set up booth and attend the Southern California Forum for Diversity in Graduate Education for UCI graduate recruitment

Department of Pharmacology, University of California, Irvine (Graduate Student Representative)

2012 - 2013

 

  • Organized department graduate student events (recruitment weekend, Winter Holiday Party, Graduate Pharmacology Retreat)
  • Set up social events to help graduate students network with each other and faculty

Graduate InterConnect program, University of California, Irvine (Peer Mentor to International Graduate Students)

2011 - 2012

  • Helped organize and volunteered at the International Graduate Student Orientation
  • Set up weekly events to help orient new international graduate students to the UCI community

Education

2010 - present
PhD in pharmacology & toxicology, in progress
University of California, Irvine

2010
MS, Biology
California State University, Long Beach (CSULB)

Research Experience

April 2011 to present
Graduate Student, Graduate Advisor: Olivier Civelli, PhD
University of California, Irvine

September 2007 – August 2010
Graduate Student, Graduate Advisor: Kevin Sinchak, PhD
California State University, Long Beach

September 2005 – August 2007
Research Technician, PI: Jonathan Kaye, PhD
The Scripps Research Institute, La Jolla, CA

September 2003 – August 2005
Research Assistant I, Supervisor: Joan Vaughan
Salk Institute for Biological Studies, La Jolla, CA

August 2002 – March 2003
Student Intern, PI: Gary Karpen
Salk Institute for Biological Studies, La Jolla, CA

Research Interests

University of California, Irvine (Graduate Student)

  • Investigated an in vivo method to activate/inactivate melanin-concentrating hormone (MCH) neurons to determine their role in neuropsychiatric disorders.
  • Examined the MCH system’s neuroanatomical connections.
  • Established an MCH neuron specific oxytocin receptor knockout line.
  • Evaluated the dose-response relationship for preclinical antagonists of the MCH system to determine their role in repetitive behaviors in a mouse model of autism spectrum disorders.
  • Identified a novel neural circuit important in regulating repetitive behavior in rodents using a broad array of behavioral assays, drug administration, stereotactic surgery and neuroanatomical tracing techniques.
  • Developed a genetically targeted technique to label MCH neuronal inputs using a rabies virus mediated approach.
  • Determined the changes in the MCH system during the estrus cycle.

California State University, Long Beach (Graduate Student)

  • Investigated the neurocircuitry controlling sexual receptivity in female rats via dual label fluorescent in situ hybridization and immunohistochemistry.
  • Carried out tract tracing study of axonal projections from the arcuate nucleus to the medial preoptic area via Fluorogold pressure injection.
  • Performed behavioral study investigating the lordosis quotient under various hormonal conditions and third ventricle applications of antagonists.

The Scripps Research Institute (Research Technician)

  • Conducted research on positive selection of thymocytes.
  • Cloned plasmid vectors for analysis via cell transfection assays.
  • Developed a protocol for multiplex ligation assay to distinguish between heterozygous and homozygous mice.

Salk Institute for Biological Studies (Research Assistant I)

  • Assisted with antisera production including preparation of injections, processing of serum, scheduling, and record keeping.
  • Assisted with biological assays of rodent tissues including chemical extraction and partial purification by column chromatography.
  • Behavioral testing and analysis of transgenic mice and preparation of tissues for immunohistochemical analysis.

Salk Institute for Biological Studies (Student Intern)

  • Assisted in the design and implementation of Drosophila crosses.
  • Maintenance of Drosophila stocks and general laboratory procurement of supplies.
  • Drosophila larval dissection (neuroblast, salivary gland) and GFP detection in larvae.

Honors and Awards

UCI Fletcher Jones Foundation Fellowship

 ($19,000)

September 2015

Henry Wood Elliott Award, Department of Pharmacology UCI ($5000)

May 2015

Pharmaceutical Research and Manufacturers of America Foundation Pre-Doctoral Fellowship in Pharmacology/Toxicology ($40,000)

December 2014

School of Medicine Student Travel Award

November 2014

Department of Pharmacology Student Travel Award

October 2014

UCI DECADE Student Travel Award

 

September 2014

Pharmacological Sciences Graduate Student Federal Work-Study Award ($10,000)

August 2014 - 2015

Pharmacological Sciences Graduate Student Federal Work-Study Award ($10,000)

August 2013 - 2014

UCI Graduate Division Student Travel Award

November 2013

Front Cover Image for Pharmacology Graduate Program Retreat

June 2012

Alliance for Graduate Education and the Professoriate (AGEP) Competitive Edge Summer Research Program Fellowship (UC Irvine, sponsored by the National Science Foundation (NSF))

2010 - 11

Finalist for Don Eden Graduate Student Research Award (CSU Program for Education and Research in Biotechnology)

January 2011

Student Travel Grant (CSU Program for Education and Research in Biotechnology)

November 2009

Associated Students Incorporated Travel Fund (California State University, Long Beach)

October 2009

Sally Casanova Pre-Doctoral Scholarship (California State University)

2009 - 2010

Provost’s Student Summer Stipend Program for Research, Scholarly and Creative Activity (California State University, Long Beach)

June 2009 

Associated Students Incorporated Travel Fund (California State University, Long Beach)

December 2008

Student Travel Grant (CSU Program for Education and Research in Biotechnology)

November 2008

Student Life and Development Student Academic Travel Fund (California State University, Long Beach)

September 2008

Graduate Research Fellowship ($9000) (California State University, Long Beach)

2008 - 2009

Provost’s Student Summer Stipend Program for Research, Scholarly and Creative Activity (California State University, Long Beach)

June 2008

Richard B. Loomis Research Award (California State University, Long Beach)

April 2008

Scholarly and Creative Activities Committee Award (California State University, Long Beach)

January 2008

Publications

PEER-REVIEWED PUBLICATIONS

  • Wang L, Alachkar A, Sanathara N, Belluzzi JD, Wang Z, Civelli O. A Methionine-Induced Animal Model of Schizophrenia: Face and Predictive Validity. Int J Neuropsychopharmacol. 2015;18(12). PMCID: 4675974.
  • Sanathara NM, Moreas J, Mahavongtrakul M, Sinchak K. Estradiol upregulates progesterone receptor and orphanin FQ colocalization in arcuate nucleus neurons and opioid receptor-like receptor-1 expression in proopiomelanocortin neurons that project to the medial preoptic nucleus in the female rat. Neuroendocrinology. 2014;100(2-3):103-18. PMCID: 4225187.
  • Parks GS, Olivas ND, Ikrar T, Sanathara NM, Wang L, Wang Z, et al. Histamine inhibits the melanin-concentrating hormone system: implications for sleep and arousal. J Physiol. 2014;592(Pt 10):2183-96. PMCID: 4227902.
  • Sanathara NM, Moraes J, Kanjiya S, Sinchak K. Orphanin FQ in the mediobasal hypothalamus facilitates sexual receptivity through the deactivation of medial preoptic nucleus mu-opioid receptors. Horm Behav. 2011;60(5):540-8. PMCID: 3210402.

BOOK CHAPTERS

  • Sinchak K, Dalhousay L, Sanathara N. Orphanin FQ-ORL-1 regulation of reproduction and reproductive behavior in the female. Vitam Horm. 2015;97:187-221.

Memberships

  • Student Member of the American Society for Pharmacology and Experimental Therapeutics
  • Student Member of the Society for Neuroscience
  • Student Member of the Society for Behavioral Neuroendocrinology