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Course Curriculum

Required Courses
(Numbers in parentheses indicate units)

Biochem 210, A-B Medical Biochemistry (10-10). Lecture, 10 hours. Classical and molecular biochemistry, including structure, function and biosynthesis of macromolecules; metabolic inter-relations and control mechanisms and biochemical genetics. Application of recent advances in knowledge of molecular bases for cellular function to disease states (diagnosis, prevention and treatment). Prerequisite: consent of instructor. **Requirement of this course is determined by the graduate program/director adviser.

Pharm 241, Advanced Topics in Pharmacology (2).  Application of pharmacological principles in disease therapy. Advanced Pharmacological mechanisms and in-depth study of drug action. Disease states and their reversal or treatment of pharmacological agents. Discussion of several major drug classes/therapeutic strategies: molecular mechanisms of action, physiological consequences of administration, and clinical use.

Pharm 251, Experimental Pharmacology (6). Introduction to the concepts and techniques used in pharmacological science. Molecular biology, quantitative pharmacology, biochemical pharmacology, methods for ion channel study, fluorescent probes, behavior genetics, anatomical analyses, pharmacokinetics and ADME, animal handling, and receptor binding analysis.

Pharm 254, Introduction to Pharmacology (4). Ligand-gated ion channels, G protein-coupled receptors, receptor tyrosine kinases, ligand-regulated transcription factors, their signaling mechanisms, trafficking, macromolecular complexes, and physiological responses.

Pharm 255, Neuropharmacology (4). Lecture, two hours; seminar, two hours. Mechanisms underlying chemical signaling processes in the brain and periphery. Molecular biology, signal transduction, transmitter synthesis and inactivation of major neurotransmitter systems.  Drugs that act on these major neurotransmitters.

Pharm 256, Experimental Design for Pharmacologists (statistics) (1). Lecture, one hour; discussion, one hour; laboratory, one hour. Population and sample statistics, hypothesis testing, analysis of variance, nonparametric statistics, experimental design, power and the use of statistical computer software.

Pharm 257, Ethics in Research (1). Lecture, one hour; discussion, one hour. Ethical conduct in research including data handling, authorship, conflict of interest, animal rights and handling of misconduct.

Pharm 298, Seminar (includes Journal Club and seminars) (2). Presentation and discussion of current problems and methods in teaching and research in pharmacology, toxicology and therapeutics.

Pharm 299, Research (1 to 12). Individual research directed toward doctoral dissertation and supervised by a particular professor. Prerequisite: consent of instructor. May be repeated for credit.

Elective Courses

Pharm 210, Chemical Neuroanatomy (4). Lecture, two hours; seminar, two hours. Organization of the nervous system, especially with respect to chemical identity of elements for students of pharmacology. Major cell types, methods of study, ultrastructure, synaptic organization of functionally defined systems, localization of chemically defined cells and receptors and brain development.

Physiol 206, A-B Medical Physiology (5-6). Lecture, six hours; discussion, two hours; other, two hours. Vertebrate physiology with emphasis on humans and on the relationship between the function of normal tissues and the processes of disease. Fundamental principles of physiology and the interrelationships that control organ function.