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Candice A. Gellner

Entered program Fall 2013
Advisor: Frances M. Leslie, Ph.D.
Candice is a Graduate Student Researcher in Dr. Leslie's lab and can be reached at cgellner@uci.edu.

Education

2013 - present
PhD in Pharmacology & Toxicology, in progress
University of California, Irvine

August 2006-May 2012
B.S. in Biochemistry
California State University, Sacramento

Research Experience

Spring 2013 - present
Understanding how the non-nicotine constituents affect models of tobacco dependence. Research Adviser: Dr. Frances Leslie
Department of Pharmacology, University of California, Irvine, School of Medicine

Winter 2012
Investigating liposomes as targeted drug delivery systems. Research Adviser: Dr. Young Jik Kwon
Department of Pharmaceutical Sciences, University of California, Irvine

Fall 2012
Warfarin inhibition of M. tuberculosis DsbG when complexed with M. tuberculosis VKOR. Research Adviser: Dr. Celia Goulding
Department of Molecular Biology and Biochemistry, University of California, Irvine

Summer 2011
Investigation of different truncations of Apolipoproteins and their use in NLPs. Research Advisor: Dr. Matthew Coleman
Lawrence Livermore National Laboratory

2010-2012
The use of nanolipoproteins (NLPs) to study over expressed proteins in breast cancer. Research Adviser: Dr. Paul Henderson
Department of Internal Medicine, Hematology and Oncology, University of California, Davis

2010-2012
Investigation, isolation, and characterization of cross-linking L178H ApoA1. Research Adviser: Dr. Linda Roberts
Department of Chemistry, California State University, Sacramento

2009-2010
Investigation of microdosing as a form of cancer treatment Investigation of the use of micelles as a drug delivery platform Using NLPs to study breast cancer. Research Advisor: Dr. Paul Henderson
Center for Biophotonics Science and Technology, University of California, Davis

Research Interests

  • Understanding how nicotine and other drugs of abuse affect the developing brain.
  • Understanding lung cancer and the influence of smoking.
  • The use of delivery platforms in cancer therapy.
  • Designing drugs to be used in delivery platforms for disease therapies.
  • Influences of cancer stem cells.
  • X-ray crystallography and the biological properties of potential drug targets.

Honors and Awards

  • Undergraduate Poster Presentation Award

            SACNAS National Conference                                                 October 2011

  • 2011 Partnerships for Innovation Commercialization Plan Award

            Accelerated Medical Diagnostics (AMD)                                    May 2011

  • Best Presentation Award

            Center for Biophotonics Science and Technology (CBST)            June 2010 – Sept. 2010

Publications

Published:

  • He, W., Scharadin, T.M., Saldana, M., Gellner, C., et al. (2015) Cell-free expression of functional receptor tyrosine kinases. Sci. Rep. 5. doi:10.1038/srep12896

 In preparation:

  • Gellner, C., Belluzzi, J., and Leslie F.M. Age Differences in Self-Administration of Nicotine and Cigarette Smoke Extract.

Conference Presentations/Abstracts

  • “Self-administration of cigarette smoke extract vs. nicotine alone in adolescent and adult male rats”

           Poster presented at Society for Neuroscience, Walter E. Washington Convention Center,Washington, DC(2014)

  •  “Concentration dependence of cross-linking L178H apolipoprotein A-I”

           Poster presented at ACS Undergraduate Symposium, Mills College, Oakland, CA (2012) 

  •   “Obtaining access to membrane proteins using cell-free technologies and nanolipoproteins”

           Poster presented at SACNAS National Conference, San Jose, CA (2011)

  • “Obtaining access to membrane proteins using cell-free technologies and nanolipoproteins”

           Scientific abstract and presentation, CBST Summer Internship Program, Davis, CA (2011) 

  • “Ex Vivo Synthesis of ErbB2/Her2 NLPs for Biochemical, Structural and Drug Development Studies”                                                                                                                                 

           Scientific abstract and presentation, CBST Summer Internship Program, Sacramento, CA (2010)

Memberships

  • Society for Neuroscience