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Gee Lab

Gee Lab

Kelvin W. Gee, PhD

Professor of Pharmacology 

BS, 1974, Biological Sciences, University of California, Irvine
PhD, 1981, Pharmacology & Toxicology, University of California, Davis
Pharmaceutical Manufacturer's Association Foundation Faculty Development Award

Summary of Research: The main focus of Kelvin Gee's UC Irvine laboratory is the characterization of novel allosteric modulatory sites on receptors that are potential drug targets for the treatment of neurological and psychiatric disorders. The design, delivery and development of novel compounds which modulate these sites can then be used to validate these targets in animal models of disease.

Currently, our laboratory is involved in two areas of drug discovery research. The first area involves allosteric modulatory sites on gamma-aminobutyric acid-A (GABAA) receptors which have therapeutic relevance for disorders such as anxiety, epilepsy and insomnia. The second area involves allosteric modulatory sites on specific nicotinic acetylcholine receptor subtypes which have therapeutic relevance for disorders such as Alzheimer's disease, schizophrenia and addiction. The development of novel compounds that selectively modulate these receptor systems represents a crucial step in the drug discovery process on the path to more effective treatments.

The Lab Personnel:

Specialists:

  • Derk Hogenkamp, PhD

Associate Specialists:

  • Timothy Johnstone, PhD

Assistant Specialists:

  • Ryan Yoshimura, PhD
Technologies & Research Capabilities
  • Medicinal chemistry
  • Electrophysiology
  • Molecular biology
  • Receptor and behavioral pharmacology